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Comparative developmental studies are valuable for understanding hominid evolution (e.g., Boesch, 2007 Johnson-Pynn, Fragaszy, & Cummins-Sebree, 2003), and essential for delineating those characteristics that are uniquely human (e.g., Bjorklund, 2006 Leavens, Bard, & Hopkins, in press). The current article presents a detailed study of the neurobehavioural integrity of newborn chimpanzees, which was part of a larger project that documented imitative (e.g., Bard, 2007 Custance, Whiten, & Bard, 1995), cognitive (e.g., Bard & Gardner, 1996 Bard, Fragazsy, & Visalberghi, 1995 Bard, Todd, Bernier, Love & Leavens, 2006), and socio-emotional development (e.g., Bard, 2009, 2005, 2003, 1998a, b Russell, Bard, & Adamson, 1996 van IJzendoorn, Bard, Bakermans-Kranenberg, & Ivan, 2009) in a comparative perspective. What are the inborn capacities of chimpanzees? How do chimpanzees compare to humans? These questions typify the long-standing scientific interest in ‘what makes us human’ (e.g., Burghardt, 2009 de Waal, 1982 Fouts & Mills, 1997 Goodall, 1986 Hayes, 1951 Kellogg & Kellogg, 1933 Wrangham, 2009 Wrangham, McGrew, de Waal, & Heltne, 1994 Zlatev, Racine, Sinha, & Itkonen, 2008). The results of this study support the conclusion that the interplay between genes and environment, rather than genes alone or environment alone, accounts for phenotypic expressions of newborn neurobehavioral integrity in hominids. The human group was indistinguishable from at least one of the chimpanzee groups in the remaining 24 of 25 NBAS scores. Surprisingly, the cross-species comparisons revealed that the human group was distinct in only 1 of 25 NBAS scores (the human group had significantly less muscle tone than all the chimpanzee groups). Among the 4 chimpanzee groups, significant differences were found in 23 of 24 NBAS scores. The cross-group and cross-species comparisons were conducted at 2 and 30 days of age. Thirty-eight chimpanzees were tested every other day from birth, and analyses revealed significant developmental changes in 19 of 27 NBAS scores. Neurobehavioral integrity related to orientation, motor performance, arousal, and state regulation of 55 chimpanzee (raised in four different settings) and 42 human newborns was measured with the Neonatal Behavioral Assessment Scale (NBAS) a semi-structured 25-minute interactive assessment. The aims of this article are to describe the neurobehavioral integrity of chimpanzee newborns, to investigate how early experiences affect the neurobehavioral organization of chimpanzees, and to explore species differences by comparing chimpanzee newborns to a group of typically developing human newborns. Please note that customers ordering with The Watersports Centre from outside the UK that the UK have now left the European Union and that on orders leaving the UK, no UK VAT will be charged and as a result the price you see and pay will exclude UK VAT. Once delivered, orders can be returned as normal subject to our usual terms and conditions. Cancelations while orders are held are not possible as at that stage we cannot recall the shipments. The issue arises with customs processing. Please be aware that customs are presently experiencing delays in some European destinations such as Spain, Italy and Germany. Orders for kitesurf boards and wing foil boards: £79.95 Country Please do not hesitate to contact us if you have any questions on this subject.Ĭountries :Austria, Belgium, Denmark, France, Germany, Holland, Ireland (including Northern Ireland), Luxembourg and Monaco. Unfortunately, if The Watersports Centre sends an item out and it is then rejected by the customer due to these import charges you will receive a full refund for the item when it is returned to The Watersports Centre less the total shipping and returns costs. The Watersports Centre is not responsible for any such charges and if they become due you should be contacted by your customs office. Orders over £250.00 (except surfboards) Free.įor customers placing orders with The Watersports Centre from Jersey, Guernsey and the Isle of Man – It is highly important (and we recommend that you check your national import policy) that you understand and budget for any import taxes that you may have to pay. Orders to the Isle of Man, Jersey and Guernsey In exceptional circumstances we may have to contact you if there is any additional charge for a particular destination. The Watersports Centre reserves the right to refuse any order and will advise the potential buyer in good time. If the goods are damaged and not signed for as such, The Watersports Centre cannot accept any liability and it will not be possible for the item(s) to be replaced or reimbursed. It is your obligation to inspect and confirm that the goods are in perfect condition before signing. If you cannot thoroughly check the goods please sign for them as “unchecked”. If any damage is visible, please ensure you sign as “Damaged” and you are with your rights to refuse to accept delivery and ask the courier to return them to the sender. Upon receipt please you are required to check all items to ensure nothing has been damaged in transit before signing for them. Next working day delivery ONLY applies for Mainland UK.Īdditional costs for larger items and next day services may apply for locations such as Scottish Islands, Scottish Highlands, Northern Ireland, Isle of Wight, Guernsey, Jersey, Isle of Man, please contact us if you need to clarify this? Orders for Next Day delivery must be placed by 1pm, but please call if it is after this time as we may be able to put Next Day orders through till 3.30pm. Orders for Surfboards, large Foil Boards and large Twin Tips: £19.95ĭelivery times are based on standard working days being Monday to Friday, no Saturday deliveries, excluding public holidays. Orders over £65 (except surfboards, large foil boards and larger twin tips) Ozone developed the Click-In function to be simple and intuitive, so activating and reloading will become second nature. Although this important safety check is often overlooked, checking your release before each session will ensure it is functioning properly. In the same way fastening your seatbelt has become a natural action when getting into a car, riders should activate and reload their release systems before and after every use. The design of the new Ozone release system, the Click-In Loop, is inspired by the same principle. What’s the first thing you do when you get in a car? You click in your seatbelt, hearing that ‘click’ sound makes you feel secure that you are safely buckled up, and you know instinctively how to release it. ‘The Click-In Loop is a step in the right direction to making your kiting experience easier, wherever your adventures may take you…’ Design Inspiration The Click-In Loop is AFNOR NF S52-503 certified. A self-positioning release mechanism locates automatically, ready to be re-loaded by simply ‘clicking’ in the loop. The release handle fits comfortably in the hand, it is quick and easy to activate the release by pushing the handle away. Ozone Click-In Loop – V4 Control System from Ozone Kites on Vimeo.Īn all-new push-away quick release with an innovative one-step Click-In reload function that is incredibly intuitive. The Mobile Station’s rugged design and OcuSync 2.0 transmission system ensures you can gain centimeter-level accurate data with your Phantom 4 RTK in any condition. New low-cost RTK survey drone packages built. Support your Phantom 4 RTK missions with the D-RTK 2 Mobile Station – providing real-time differential data to the drone and forming an accurate surveying solution. DJI Phantom 4 RTK + D-RTK 2 Combo, 20MP CMOS Sensor, RTK, TimeSync, 7km OcuSync Transmission, 30min Flight Time. This video details the in field setup workflow of the DJI Phantom 4 RTK using the D-RTK 2 Mobile Base Station. Seamless Compatibility with D-RTK2 Mobile Station The distortion parameters gathered are saved into each image’s metadata, letting post-processing software adjust uniquely for every user.Įnjoy stable and reliable HD image and video transmission at distances of up to 7 km, great for mapping larger sites. Support your Phantom 4 RTK missions with the D-RTK 2 Mobile Station providing real-time differential data to the drone and forming an accurate surveying solution, or acquire accurate location coordinates when used as an RTK rover. To ensure each Phantom 4 RTK offers unparalleled accuracy, every single camera lens goes through a rigorous calibration process where radial and tangential lens distortions are measured. Seamless Compatibility with D-RTK 2 Mobile Station. Due to the high resolution, the Phantom 4 RTK can achieve a Ground Sample Distance (GSD) of 2.74 cm at 100 meters flight altitude. Mechanical shutter makes mapping missions or regular data capture seamless as the Phantom 4 RTK can move while taking pictures without the risk of rolling shutter blur. Learn about our consumer drones like DJI Mavic 3 Classic, DJI Mini 3 Pro, DJI Air 2S. Capture the best image data with a 1-inch, 20 megapixel CMOS sensor. DJI technology empowers us to see the future of possible. The sunscreen sits on top of the skin and physically shields it from harmful UV rays, says Dr. Mineral sunscreen, sometimes referred to as a physical blocker or physical sunscreen, contains either zinc oxide or titanium dioxide (and sometimes both).Below are some more details about the difference between mineral and chemical sunscreens: Deborah Spey, a board-certified dermatologist at Schweiger Dermatology Group. While mineral and chemical sunscreens are both proven to be “safe and effective in reducing short- and long-term sun damage and skin cancer,” the difference is how they protect you, says Dr. SKIP AHEAD The best mineral sunscreens| How to shop for mineral sunscreens | Limitations of mineral sunscreens | The best way to apply mineral sunscreen Mineral vs. “Both UVA and UVB rays come from the sun and cause DNA mutations that are signatures in skin cancers and skin aging,” says Rossi. Anthony Rossi, a board-certified dermatologist at Memorial Sloan Kettering Cancer Center. The reason: Unlike chemical sunscreens, mineral sunscreens are naturally broad spectrum, meaning they offer protection against UVA and UVB rays as a baseline, no matter which brand or variation you buy, says Dr. However, not all sunscreens are created equal - some dermatologists favor mineral sunscreen over chemical sunscreen. And warmer weather often means more exposure to the sun, which could put you at greater risk for sun damage if you’re not slathering on the sunscreen. Most skin care experts say wearing sunscreen every day is essential to help reduce the potential for sunburns and skin cancer as well as wrinkles and other signs of aging. Other Occasions & Loved Ones Gift Guides All Other Occasions & Loved Ones For Teens For Grandparents For Bridal Shower For New Parents For Any Occasion Holiday Season & Christmas Gift Guides All Holiday Season & Christmas Last Minute Gifts Gifts under $25 Practical Gifts Tech Gifts Diy Gifts Graduation Gift Guides All Graduation For College Grads For High School Grads For Teachersįather's Day Gift Guides All Father's Day Best Father's Day Gifts For Dads Who Love Fishing Last Minute Gifts Best from Amazon Mother's Day Gift Guides All Mother's Day Last Minute Gifts Best Mother's Day Gifts For Moms Who Have Everything Best from Amazon Valentine's Day Gift Guides All Valentine's Day For Her For Pets & Pet Owners For Any Loved Ones Pet Care Pets All Pet Care Nail Clippers Flea & Tick Cameras Smart Gadgets Tech All Smart Gadgets Smart Watches Bulbs Garage Door Openers SecurityĬomputers Tech All Computers Laptops Gaming Laptops Laptops for College Students Computer Monitorsĭogs Pets All Dogs Dog Food Dog Carriers Dog Beds Dog ToysĬats Pets All Cats Cat Food Litter Boxes Scratching Posts Cat Carriers Cat Toys Headphones Tech All Headphones Over Ear Noise Canceling Wireless Earbuds Outdoor Home & Kitchen All Outdoor Raised Garden Boxes Garden Hoses Gas Grills Beach TowelsĮlectronics Tech All Electronics Tvs Wifi Routers Gaming Consoles Streaming Devices Office Home & Kitchen All Office Office Chairs Standing Desks Desk Organizers Seat Cushions Under Desk Ellipticals Small Home Appliances Home & Kitchen All Small Home Appliances Vacuums Air Conditioners Space Heaters Humidifiersīedding & Bath Home & Kitchen All Bedding & Bath Sheets Bath Towels Silk Pillowcases Duvet Inserts Kitchen Appliances & Tools Home & Kitchen All Kitchen Appliances & Tools Coffee Makers Cookware Air Fryers Mixers Kitchen Gadgets Sleep Wellness All Sleep Mattresses Pillows Blackout Curtains Sound Machines Health Wellness All Health Meal Kit Delivery Kn95 Masks Air Purifiers Eco-Friendly Laundry Detergentsįitness Wellness All Fitness Exercise Bikes Dumbbells Walking Shoes Fitness Trackers Oral Care Wellness All Oral Care Electric Toothbrushes Toothpastes Whiteners Floss Hair Care Wellness All Hair Care Shampoos Purple Shampoos Thinning Hair Head Shavers Flat Irons Hair Dryers Skin Care Wellness All Skin Care Moisturizers Sunscreens Acne Teen Acne Rosacea Lip Balms Under Eye Patches For monks, whose daily schedule was divided between working and praying, the reading and making of manuscripts were acts of devotion. Idea Four: What kinds of books were illuminated?ĭuring the Middle Ages, Christianity played a dominant role in European life. This picture shows how a book was sewn together. The feathers have been removed and the tip is being cut into a point. Here we see a scribe preparing a quill for writing. Often metal clasps or leather ties would hold the book shut. Next the pictures, border decorations, and ornamented letters were painted, in colors made from natural pigments.įinally, all of the pages were folded, sewn together, and bound between covers of wood or leather. The illuminator applied small, delicate sheets of gold or silver leaf with a wet glue and then polished with a smooth stone or even a hound’s tooth. First, gold or silver was put on, a process called gilding. When the scribe finished the writing, the illuminator went to work painting the illustrations and decorations. Most scribes knew several writing styles, and a person commissioning a book could select the lettering style. The lines of text were fairly short, usually no more than four to nine words each. Then he began, writing in ink with a quill pen made from a goose or swan feather. The skins were cleaned, stretched, scraped, and whitened with chalk to provide bright, strong, and smooth pages for writing.īefore starting to copy a text, the scribe marked the margins of the page and ruled lines to write on. Manuscripts were written on either vellum (calf skin) or parchment (sheep or goat skin). Idea Three: How was an illuminated manuscript made?Ī close look at this manuscript reveals the ruled lines that were a guide for the scribe. This painting shows a cardinal writing in his study. The artist for this manuscript, Bonaventura a Montepulciano, signed and dated this work at the lower frame of the miniature A person who wanted a book would order it through a bookseller, who hired scribes and illuminators to do the work. Making illuminated manuscripts became a business conducted in cities. The rise of universities and the middle class created a demand for books, and book production became a way to make money. One monk might do the writing and another the illuminating.Īfter the twelfth century, monks were no longer the only scribes. Sometimes the same person was both scribe and illustrator, but not necessarily. Scribes worked in a writing room called a scriptorium. He might travel quite a distance to borrow one from another monastery, and even stay there to do his copying. To make a new manuscript, a monk had to obtain a book to copy. However, rulers and high-ranking churchmen commissioned books from monastaries, including historical records and Greek and Roman literature. Monks copied books mainly for use in worship. Before universities existed, monasteries were the central places for learning. In early medieval times, monks were the sole makers of illuminated manuscripts. Idea Two: Who made illuminated manuscripts? This close-up of the border allows us to see where gold leaf was applied. The miniature depicting Christ’s Crucifixion is also a decorated letter C. 1425-1464īrown and red ink, gouache, and gilding, and leadpoint ruling on vellum This illuminated manuscript is decorated with an elaborate border and a miniature painting.Ĭrucifixion with a Crowd of Supplicants, c. The making of illuminated manuscripts continued strong until the 1450s, when a German man named Johannes Gutenberg invented movable type and the printing press, making mass production of books possible. The pictures were especially important because during medieval times, many people, even those who owned manuscripts, could not read. Such decorations illustrated the text and helped guide people through it. Medieval manuscript decoration included small painted scenes (called miniatures), intricate borders, ornate chapter letters, and even elaborate full-page paintings. Gold was usually applied to the pages in extremely thin sheets called gold leaf. The word “illuminated,” from the Latin illuminare, means “lighted up.” For a book to truly be illuminated, it had to be decorated with gold. A scribe would obtain a book to copy and painstakingly write out every word, in ink with a quill pen. The word “manuscript” from the Latin words manus (hand) and scriptus (writing) literally means “written by hand.” Before the invention of printing, copies of books had to be handwritten. Possibly The School of the Master of Mary of Burgundyexpand_more Leaf from a Book of Hours (recto and verso), late 15th century Idea One: What is an illuminated manuscript? IU School of Medicine is the largest medical school in the U.S. “Prevention is better in the long run, so our goal is to be able to provide a comprehensive report for patients and their physicians using simply one tube of blood.” “This is something that could be a panel test as part of a patient’s regular wellness visits to evaluate their mental health over time and prevent any future distress,” Niculescu said. Researchers can also use the test to develop new treatments for anxiety that are more targeted to individual biomarkers. Niculescu said this new test could also be used in combination with the other blood tests his research has led to, providing a more comprehensive view of a patient’s mental health and risk of future mental health concerns. “If we can know that earlier, then we can hopefully avoid this pain and suffering and treat them earlier with something that matches their profile.” “There are people who have anxiety and it is not properly diagnosed, then they have panic attacks, but think they're having a heart attack and up in the ER with all sorts of physical symptoms,” Niculescu said. Niculescu said the test can help evaluate a person’s risk of developing higher levels of anxiety in the future as well as how other factors might impact their anxiety, like hormonal changes. “But having something objective like this where we can know what someone’s current state is as well as their future risk and what treatment options match their profile is very powerful in helping people.”Ī person’s biomarkers can also change over time. “In addition to medications, there are other methods to treat anxiety, such as cognitive behavioral therapy or lifestyle changes,” Niculescu said. By examining the RNA biomarkers in their blood, researchers could identify a participant’s current state of anxiety and match them with medications and nutraceuticals, showing how effective different options could be for them based on their biology. Participants completed a blood test every three to six months or whenever a new psychiatric hospitalization occurred. It included three independent cohorts: discovery, validation and testing. This latest study uses similar methods for anxiety. Niculescu’s past research has led to the development of blood tests for pain, depression/bipolar disorder and post traumatic stress disorder. We wanted to see if our approach to identify blood biomarkers could help us match people to existing medications that will work better and could be a non-addictive choice.” “The current approach is to talk to people about how they feel to see if they could be on medications, but some medications can be addictive and create more problems. “Many people are suffering from anxiety, which can be very disabling and interfere with daily life,” said professor of psychiatry Alexander Niculescu, MD, PhD. The researchers’ results were recently published in Molecular Psychiatry, and the blood tests are currently being developed for wider use by physicians by Indianapolis-based startup MindX Sciences, which was founded on science developed at IU School of Medicine. The test examines biomarkers that can help them objectively determine someone’s risk for developing anxiety, the severity of their current anxiety and which therapies would likely treat their anxiety the best. INDIANAPOLIS-Researchers from Indiana University School of Medicine have successfully developed a blood test for anxiety. New test is the latest in a series of blood tests for mental health disorders It should be noted that Microsoft is expected to bring a better and improved Windows Copilot digital assistant with ChatGPT capabilities to deliver better user experiences on Windows and all other compatible devices in the market. 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Bekijk iconische monumenten, zoals het Empire State Building, Times Square en de Brooklyn Bridge. Customize your itinerary and enjoy New York sightseeing at your own pace! New York: hop on, hop off-sightseeingtour met een Big Bus Bewonder de belangrijkste bezienswaardigheden en populairste wijken van New York vanaf het bovendek van een open hop on, hop off-bus. Enjoy new, state-of-the-art audio commentary that is highly entertaining and engaging for adults and children available in 6 languages. The Uptown Tour convers parts of Midtown, including Grand Central Station, Central Park as well as The Metropolitan Museum of Art.Ĭustomize your own itinerary and travel around the enchanting city on open-top, double-decker buses. The Downtown loop covers NYC attractions like Times Square, the Empire State Building and the iconic Brooklyn Bridge. Hop on and off at more than 10 points of interest and make your way around the city without having to worry about getting lost in the subway or hailing a cab.Įnjoy sightseeing for 1 or 2 days with your ticket that gives you access to the Downtown loop and Uptown Tour. Whether you need a bus for wedding transportation, corporate conferences, sporting events, or any other occasion, we’re here to make your trip run smoother.Discover the best of the city that never sleeps on an action-packed New York hop-on, hop-off bus tour. Experience all the events and destinations the New York region has to offer. Our bus reservation specialists will help build your itinerary and coordinate a flawless trip to the big city when you call us at 1-85. Make a list of all of the sites you want to see, the boroughs you want to explore, and the things you don’t want to leave without experiencing. This is just a sample of what’s possible for a hop-on hop-off tour in New York City. map with red dots for the cities, reduced to the size. Visit the reflection pool and museum which tells the story of 9/11 and honors those who were lost that day. Boston Old Town Hop-On, Hop-Off Trolley and Summer Nights Trolley Tour. Actually I dont know what kind of response youll get these days but dont even think of using the bus as transport to get closer to an airport. You really cant take it upstairs and probably dont want to leave it downstairs. Head to the September 11 Memorial for a tour your group will never forget. Re: Luggage on Hop on Hop off bus 9 years ago Save Its a problem. Here you can catch a ferry to the Statue of Liberty on Ellis Island. Your driver will meet you on the other side of the bridge and take you to Battery Park. Day 2: Sightseeing in Downtown NYCīeginning at New York City Hall, walk across the Brooklyn Bridge into DUMBO for brunch at Atrium. You can find incredible views of the city on the 86th and 102nd floors.Įnd the day with a stroll down Shubert Alley, a historical landmark in the world of theatre, before attending a performance of one of Broadway’s award-winning shows. Stop at the Empire State Building to admire the building’s height and history. Next, take a selfie with your favorite celebrity look-alike at Madame Tussauds Wax Museum. Your driver will take you to Times Square for a delicious lunch at restaurants like Carmine’s Italian Restaurant or Dos Caminos. After exploring the park, walk over to the Guggenheim Museum or the Metropolitan Museum of Art. Start your morning in Manhattan with a ride to Central Park. Keep reading for an example of a 2-day tour with our top recommendations. We’ll help you craft the perfect itinerary for your group trip, incorporating the NYC destinations that best fit your interests. Hop-on the bus for panoramic views from your bus seat, and hop-off to experience NYC’s top attractions.Īvoid the poorly marked routes, long lines, and rigid itineraries of traditional tour bus services by renting your own bus through GOGO Charters. New York City’s hop-on hop-off bus tours offer visitors a ride to iconic landmarks throughout the city. |
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